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Future recommendations suggest its use in different types of apitherapy for the treatment of different human and animal diseases and physiological alterations

FOXO4-DRI may reduce age-related inflammation Senescent cells often release pro-inflammatory factors known as the senescence-associated secretory phenotype (SASP)

Furthermore, IS activates NF-B signaling, increasing pro-inflammatory factors such as cyclooxygenase-2, ROS, TNF-, IL-6, and IL-1, while suppressing antioxidant factors such as heme oxygenase-1 and superoxide dismutase 2, through Nrf2 pathway inhibition, thereby disrupting intestinal homeostasis and promoting systemic inflammation in mice ( Figure 3 ) [116]